The haptoglobin genotype Hp 1-1 is a new potential risk factor for knee osteoarthritis

Metabolic Syndrome as a Risk Factor for Osteoarthritis

  Metabolic syndrome refers to a set of conditions that include high blood pressure, increased insulin level in the blood, the accumulation of the excess fat around the abdomen, and increased blood lipids. In metabolic syndrome, the vast majority of these conditions are simultaneously present, and the risk of developing heart disease, stroke, and diabetes rises. Besides, osteoarthritis or degen...

ANALYSIS OF THE HAPTOGLOBIN PHENOTYPE (Hp 1-1, Hp 2-1, Hp 2-2) IN CEREBRAL MALARIA CASES OF INDIAN PATIENTS

Haptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind free hemoglobin (Hb) and prevents the loss of iron and subsequent kidney damage following hemolysis. In human, the Hp locus is polymorphic with two co-dominant alleles (Hp1 & Hp2) that yield three distinct genotype/ phenotype (Hp 1-1, Hp 2-1, Hp 2-2).The haptoglobin phenotype of Indian patients of malari...

Haptoglobin 1-1 Genotype Is AssociatedWith Poorer Cognitive Functioning in Type 2 Diabetic Elderly

RESULTSdIn the present analysis, 812 subjects participated (84 with Hp 1-1, 335 with Hp 1-2, and 393 with Hp 2-2 genotypes). Average was 72.9 years of age (SD 4.7), and Mini Mental State Exam (MMSE) was 28.0 (SD 1.8). Compared with subjects with Hp 1-2 genotype, Hp 1-1 subjects performed significantly worse in semantic categorization (F = 7.03; P = 0.008) and the overall cognitive score (F = 5....

Mediopatellar Plica as a Risk Factor for Knee Osteoarthritis?

Potential Influence of Interleukin-1 Receptor Antagonist Gene Polymorphism on Knee Osteoarthritis Risk

OBJECTIVES Genes encoding for cytokines have been associated with susceptibility for joint osteoarthritis (OA) and interleukin (IL)-1 gene is supposed to be involved in the cartilage destruction process. In this regard, interleukin-1 receptor antagonist (IL-1RA) competing with IL-1 for binding to its receptor may act as an inhibitor of cartilage breakdown. We assessed the association of primary...